Repeat Dose Toxicity

The repeat dose toxicity is a critical factor in pharmaceutical and chemical safety assessments. It refers to the adverse effects that occur due to prolonged exposure to a substance over an extended period. Evaluating repeat dose toxicity is essential in preclinical studies to determine safe dosage levels and identify potential health risks. Regulatory agencies, such as the FDA and EMA, require thorough repeat dose toxicity testing to ensure product safety before market approval. Researchers use various models, including in vivo and in vitro testing, to assess organ-specific toxicity and cumulative effects. Understanding repeat dose toxicity helps in developing safer drugs and chemicals while minimizing long-term health hazards.